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Reduced-frequency alternatives include 2 to 3 mg three times per week or 2 mg every other day, producing similar weekly exposure with fewer injections

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B12 is a water-soluble vitamin vital to various bodily functions, including energy production, red blood cell formation, and nervous system support

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Therefore, there is increasing interest in regenerative therapies aimed at the biological repair of the degenerated IVD, including cell-based strategies and the use of growth factors or gene therapy

(As described by OCallaghan and Fenech 2011)