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55 SakamotoK.YonokiY.KubotaY.KuwagataM.SaitoM.NakaharaT.et al (2006)

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In KEYNOTE-426, patients with previously untreated metastatic RCC were treated with either pembrolizumab (anti-PD-1) and axitinib (VEGFR1, 2, and 3 inhibitor) combination therapy or sunitinib monotherapy, and significantly increased progression-free survival (PFS) was demonstrated in the combination group compared with the sunitinib group 93

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