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The technology is currently one of the most active research areas, and has enormous potential for application in nanomedicine

doi: 10.1038/nature08595
As one of the main components, crocin improved depressive symptoms and reduced the expression of inflammatory cytokines (e.g., IL-1, IL-18, and TNF-) in the hippocampus of LPS-depressed mice (96)

Ballesteros AF, Brabenec O, Tsagkaris AS, Ares AM, Hajslova J, Bernal J

Reduced pro-inflammatory adipokines and elevated anti-inflammatory adipokines were found in the serum (174, 175)

However, G6PD deficiency is not the only factor since diabetes is a complex multifactorial metabolic disease
