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Notably, NRF2-inducing compounds, such as tBHQ and sulforaphane, modify distinct KEAP1 residues from oxidation by ROS, thus allowing for an additive effect in the presence of oxidative stress (Suzuki et al., 2019

Additionally, as a surface protein, DPP4 serves as a promising target for DPP4-specific antibodies, enabling selective elimination of senescent cells [24]

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Dec 2016;30(12):1181-1197

doi: 10.1084/jem.20160061 71 SaraivaALVerasFPPeresRSTalbotJde LimaKALuizJPet al

Peptides offer this multi-modal potential, with different compounds addressing inflammation, neural function, sleep quality, and tissue health through distinct mechanisms that can combine synergistically
