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A placebo-controlled trial published in Molecular Psychiatry showed that high-dose folinic acid (2 mg/kg/day) for 12 weeks led to significantly greater gains in language among FRA-positive participants Nature

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Accordingly, feeding worms with DB - a diet deficient in low molecular weight (LMW) thiols, increases the lifespan of wt animals by 58%, but only marginally affected nuo-6 worms (12% increase, Supplementary Fig