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Through its interactions with sulfur and nitrogen metabolism, with ROS and ascorbate via peroxidases and DHAR, with NADPH via GR, with protein thiol-disulfide groups through GRX, and with signaling metabolites and hormones via GSTs, glutathione is an outstanding candidate as a central hub molecule whose status can modulate other signaling pathways

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Understanding the mechanisms of ferroptosis in NAFLD is essential for devising innovative treatment approaches (Fig

PMID 19640955

Additional variants in selenoprotein genes may mitigate the effect of selenium status on the risk of prostate cancer (77, 78)

The main involved enzyme families are: glutathione reductases, glutaredoxins, glutathione peroxidases, peroxiredoxins, and glyoxalases