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Recently, a multi-center RCT compared the efficacy of intralesional HA with verapamil in treatment of PD, indicating that HA has greater effectiveness on improvement of penile curvature and patient satisfaction ( Collagenase Clostridium Histolyticum Collagenase clostridium histolyticum (CCH), previously used in treating Dupuytren contracture, possesses anti-fibrotic properties by degrading the collagen and is the only FDA - approved intralesional drug for treatment of PD (Wiseman et al., 2019)