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Bacterial tryptophan metabolism metabolites are considered to take part in the development of hypertension and chronic kidney failure (120, 121)

A lumbar compression fracture occurs when a vertebra in the lower spine (L1L5) collapses due to excessive pressure, often from trauma or weakened bone (like osteoporosis)

Cancer Lett 228(12):163170 Briukhovetska D et al (2021) Interleukins in cancer: from biology to therapy

Though the exact mechanism is not well understood, it is thought that estrogen deficiency leads to down regulation of the expression of transcellular calcium transport proteins plasma membrane calcium pump 1b (PMCA1b), transient receptor potential cation channel subfamily V member 5 (TRPV5) and calbindin-D 28K (CaBP28k) [95]
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Timing prevents premature assessment of dissolution completion