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Ferrous iron, another essential trigger for the occurrence of ferroptosis, was also found to be significantly accumulated in the E8w+1B livers (Fig

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89 Additionally, the binding affinity between protein disulfide-isomerase (P4HB) and prostaglandin G/H synthase 2 (PTGS2) is enhanced by lactylation of P4HB at K311, subsequently leading to SH3-domain-containing GRB2-like protein B1 (SH3GLB1)-mediated mtROS accumulation and coiled-coil domain-containing protein 2 (NDP52)-induced mitophagy

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Recent studies have shown that plasma proteins act not only as sinks for HOCl, but get actively transformed into modulators of the cellular immune response through N-chlorination

In a cell-based model induced by excessive dopamine, L-theanine exhibited neuroprotective effects on neuronal injury through the release of body fluid molecules from astrocytes, such as glutathione (36)