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330 Another PRMT5 inhibitor, JNJ-64619178, has shown long-term PRMT5 inhibition and potent anti-tumor effect in lung, pancreatic, and hematological tumors

doi: 10.1093/bib/bbab485 165 LiX.JiangS.TappingR

The combination of lnc MEG3 and miR-145-5p reduced miR-145-5p content, upregulated the expression of its downstream target RTKN , activated the Wnt/-catenin pathway and its downstream effector Myc, promoted the expression of lnc MEG3, and aggravated renal injury

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As random changes tend to fluctuate, a steady progressive increase is unlikely to be due to chance