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Alternative 1: TB-500 (Thymosin Beta-4) What it is : Synthetic version of thymosin beta-4

Glia within the NVU are crucial components that ensheathe the endothelium forming a socalled secondary barrier, and nutrients required for CNS function are delivered from the blood vessels to neurons mainly via glia cells (reviewed by (Hurley et al., 2015)), while waste compounds are passed via glial cells to microglia or back into the bloodstream (reviewed by (Marina et al., 2018))

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These data suggest that charge alone is not killing the cells in culture, but that apoptosis is specific to an intracellular action of the peptides on senescent cells