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The defection of mitophagy will lead to the accumulation of dysfunctional mitochondria, resulting in the leakage of Cytc into the cytoplasm to induce the activation of the caspase signaling pathway, and contribute to cell death (Sinha et al., 2013
We designed two peptides to enhance cellular uptake and facilitate nuclear localization by introducing CPP sequences

MIC-B12 is a longevity-protocol compound with documented effects on the relevant biological pathway

Bond, J., T.S

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