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(Springer International Publishing AG, Cham, Switzerland), 128

Hepatotoxicity: A review published on PubMed Central (PMC) highlighted concerns about liver stress with prolonged, high-dose glutathione use

Animal studies have documented significant improvements in Morris water maze performance, radial arm maze accuracy, and novel object recognition tasks, with effects persisting for extended periods after treatment suggesting lasting changes in neural connectivity rather than temporary pharmacological stimulation

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doi: 10.1016/j.cgh.2022.01.011 100

All species generate NADPH intracellularly, which fuels disulfide reductase systems Mammals have an NADPH-independent disulfide reductase system fueled by methionine Transsulfuation reversal allows Met-fueled reductase system yet makes Met essential Transsulfuration reversal and a Se- dependent TrxR family co-evolved with metazoans Metazoan selenoprotein TrxR1 and transsulfuration each support redox signaling Acknowledgments Funding to the authors came from the US National Institutes of Health (AG055022 and CA215784)