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The angiotensin-II receptor blocker (ARB) losartan demonstrated protective properties against PIPN in experimental rats

Strategies aimed to increase cytosol GSH (e.g., NAC) may not be an optimal approach for boosting mGSH and therefore for treatment of SH or AD, as it would result in mainly increasing cytosol GSH without replenishing mGSH levels A new approach has been exploited recently in several contexts by the development of a series of cationic antioxidants targeted to mitochondria, including derivatives of the endogenous antioxidants ubiquinol (MitoQ), alpha-tocopherol (MitoVit E), and of the synthetic spin trap PBN (MitoPBN

Its main mechanism appears to be its interaction with the nitric oxide (NO) system and its ability to upregulate growth factors like Vascular Endothelial Growth Factor (VEGF)

An Acute Bout of High-Intensity Interval Training Increases the Nuclear Abundance of PGC-1 and Activates Mitochondrial Biogenesis in Human Skeletal Muscle

littoralis larvae ( n = 5 for each treatment) were collected

Metformin-associated lactic acidosis: current perspectives on causes and risk