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Lysophosphatidylcholine acyltransferase-3 (LPCAT3) and acyl-CoA synthetase long chain family member 4 (ACSL4) are the crucial enzymes regulating PUFAs biosynthesis and remodeling by catalyzing AA to phospholipid (PL) hydroperoxide (PL-OOH, such as AA-OOH), which are considered specific biomarkers and drivers of ferroptosis (Xu et al., 2020

Caffeic acid phenethyl ester suppresses the activation of Toll-like receptor 4 (TLR-4) and NF-B in macrophages that are activated by lipopolysaccharide (LPS) [52]

5 Moreover, the levels of omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (20:5n-3/EPA) and docosahexaenoic acid (22:6n-3/DHA), are considered deficient compared to marine fish

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