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In summary, these studies in regenerating sensory organs suggest that active Wnt/-catenin signaling can increase the extent of mitotic hair cell regeneration (Figure 4), yet the ability of activating Wnt/-catenin signaling alone to renew proliferation and hair cell regeneration observed in the neonatal, immature mammalian cochlea appears limited in the mature, mammalian cochlea

Side effects may include nausea, abdominal pain, and allergic reactions, emphasizing the necessity for physician guidance

139 Initially, it was hypothesized that the loss or reduction of ABCG2-mediated renal urate secretion would result in increased renal urate reabsorption, as diminished renal excretion is typically considered the primary mechanism of hyperuricemia in most gout patients

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The Q statistic and Eggers test were used to assess heterogeneity and risk of publication bias, respectively