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(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

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Advanced Protocol (Experienced Users) Daily Dose : 2-2.5 mg subcutaneous injection (0.025 mg/kg body weight) Timing : Split dosing morning and evening Frequency : Daily for intensive cycles Duration : 6-8 weeks with careful monitoring Advanced dosing should only be attempted by experienced users who have established tolerance