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Inhibiting IDH1 reduces damage and apoptosis in Ox-LDL-treated macrophages while increasing Nrf2 levels, thereby decreasing foam cell formation (Li B

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However, taking very high doses of any single mineral for a long time can sometimes affect the balance of others, which is why a well-formulated, balanced supplement routine is the best approach.

Abbreviations A549: Human lung epithelial cells ALF: Artificial lysosomal fluid AM: Alveolar macrophages AMF: Alternating magnetic field ARDS: Adult respiratory distress syndrome ART: Artemisinin ATF: Transcription factor BALF: Bronchoalveolar lavage fluid BAs: Bile acids BEAS-2B: Human lung epithelial cells Caco-2: Human intestinal epithelial cells CCL2: Monocyte chemoattractant protein-1 CDT: Chemodynamic therapy CENs: Complex engineered nanomaterials CNS: Central nervous system DCF: Dichlorofluorescein DDR: DNA damage response DFO: Deferoxamine Drp1: Dynamin-related protein 1 EGCG: Epigallocatechin-3-gallate eIF-2: Eukaryotic initiation factor-2 EMT: Epithelialmesenchymal transition ER: Endoplasmic reticulum GSH-Px: Glutathione peroxidase Hb: Hemoglobin HDF: Human dermal fibroblasts HepG2: Human hepatocellular carcinomas HIF-1: Hypoxia-inducible factor 1 HSP: Hesperidin IL-8: Interleukin-8 IRE-1: Inositol-requiring enzyme 1 LDH: Lactate dehydrogenase lncRNA: Long noncoding RNA LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MDA: Malondialdehyde MEG3: Maternally expressed gene 3 MIP-1: Macrophage inflammatory protein-1 miR-21: MicroRNA-21 MMPs: Matrix metalloproteinases mNiO: Mesoporous nickel oxide mNiOTb: Mesoporous nickel oxide terbium MNPVs: Magnetic nanoparticle-vesicle assemblies MPs: Microparticles MSM: Malignant skin melanoma NAC: N-acetylcysteine NBNs: Nickel-based nanomaterials Ni FPs: Nickel fine particles NiO: Nickel oxide NIR: Near-infrared NO: Nitric oxide NPs: Nanoparticles PDA: Polydopamine PEG: Polyethylene glycol p-eIF-2: Phosphorylated eIF-2 PERK: Pancreatic ER kinase Pink1: PTEN-induced putative kinase 1 PT: Proximal tubular PTT: Photothermal therapy RCD: Apoptosis ROS: Reactive oxygen species SD: SpragueDawley TEM: Transmission electron microscopy TGF-1: Transforming growth factor-1 TIMPs: Tissue inhibitors of metalloproteinases TNF-: Tumor necrosis factor-alpha UPR: Unfolded protein response UTI: Urinary tract infection References Liu Y, Zhu S, Gu Z, Chen C, Zhao Y