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Guarnotta V, Emanuele F, Amodei R, Giordano C

The present review focuses on the following key categories of disorders closely associated with cognitive impairment: Neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD), which are pathologically characterized by the progressive loss of neurons in specific brain regions and the abnormal aggregation of functional proteins (7), and diabetes-associated cognitive impairment (DACI), which is caused mainly by factors such as insulin resistance and neuroinflammation (8)

doi: 10.1016/j.jot.2020.09.006 49 FelteliusNLindhUVengePHallgrenR

doi: 10.1016/j.ymgme.2023.107630

Genetic Factors: Variations in genes responsible for Glutathione synthesis and recycling can influence individual differences in Glutathione levels

This redox imbalance leads to an increased risk of metabolic complications [197,198] and acceleration of telomeric attrition in the pathogenesis of MetS [199] (Table 1)