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Metabolically generated HO is further detoxified by a range of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase, to maintain intracellular redox homeostasis

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Concurrently, the expression of HMG-CoA synthasea pivotal ketogenic enzymemay undergo analogous modulation, while HMG-CoA reductase activity (its downstream counterpart) is suppressed, thereby reducing fatty acid conversion to cholesterol

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However, the comparisons carried out for the control group separately resulted in a very different list of differentially expressed miRNAs ( Supplementary File S10, Sheet 3 ) that were found to target genes enriched in pathways as shown in Supplementary File S10, Sheet 4