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The PINK1 and Parkin mediated pathway represents the most well characterized inducer of mitophagy

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Similarly, other studies have demonstrated a direct association between kidney IGF1R expression and the severity of RCC.41,42In vitro studies using RCC cell lines have shown that treatment with neutralizing antibodies against IGF1R can reduce IGF1R expression and inhibit cell proliferation

Hasanuzzaman M, Bhuyan M, Anee TI, Parvin K, Nahar K, Mahmud JA et al (2019) Regulation of ascorbate-glutathione pathway in mitigating oxidative damage in plants under abiotic stress