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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Rudolphi B, Zapp B, Kraus NA, Ehebauer F, Kraus B, Kraus D

NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

Carter, R., Mouralidarane, A., Ray, S., Soeda, J

For example, turning food into fuel, protecting your nervous system, and making the red blood cells that carry oxygen everywhere

All mechanistic discussions remain exploratory in nature and are strictly limited to non-clinical laboratory research environments

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