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39 Hippocampal atrophy in schizophrenia has been linked to neuronal atrophy and loss of neuropil, 74 which may be a consequence of redox dysregulation, although other factors such as inflammation and hypothalamicpituitaryadrenal axis dysfunction have also been shown to be important for hippocampus integrity

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The three main factors are: (1) the unresolved causes of DPN