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It is indeed well established that the subclinical inflammatory status induced by sleep deprivation has pathogenic implications for metabolic and CV risk factors (glucose metabolism, diabetes, hypertension, atherogenic lipid profile, endothelial dysfunction, and coronary calcification) and outcomes (stroke and coronary heart disease) 24

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Consistency: Administer at consistent intervals each day to maintain stable B12 exposure

doi: 10.1038/leu.2015.240 11 KrejcikJCasneufTNijhofISVerbistBBaldJPlesnerTet al

Influence of timing and intensity of musclar exercise on temporal patterns of plasma cortisol levels