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Patients in Cluster 3 reported significantly higher percentages of brain fog (91.9%), unrefreshing sleep (85.5%), memory problems (73.5%), feeling of weakness (66.3%), sore/painful muscles (61.3%), and insomnia (54.1%) than those in Cluster 2

These mitochondrial DAMPs and oxidants prime and activate the microglial NLRP3 inflammasome assembly, drive caspase-1 cleavage, and mature IL-1/IL-18, all of which contribute to the maintenance of neuroinflammation in the substantia nigra

These findings underscore lipid peroxide accumulation as a hallmark of ferroptosis, and suggest that downregulating ACSL4, LPCAT3, LOXs, or POR can suppress PUFA-PL-OOH formation and effectively inhibit ferroptosis

5.3 Different TCM pattern types of AMS and the rules of clinical application of TCM According to the theory of TCM and the principle of pattern differentiation and treatment, the main TCM pattern types of AMS are a pattern of Qi deficiency with blood stasis, and the main principle of treatment is activating Qi, activating blood circulation, and resolving phlegm (Feng et al., 2013

doi: 10.3389/fmicb.2020.01648 145 SinghS.YoussefE

* DETOXIFICATIONGlutathione is involved in detoxification by binding to fat-soluble toxins, such as heavy metals, solvents, and pesticides, and transforming them into a water-soluble form that can be excreted in urine