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(2016) 106:e2434

When the body lacks this vital vitamin, several symptoms can occur: Common Symptoms: Fatigue and weakness Tingling or numbness in hands and feet Memory issues Mood swings or depression Loss of appetite Common Causes: Vegetarian or vegan diet (B12 is mostly found in animal-based foods) Poor gut absorption Long-term use of certain medications (e.g., metformin, antacids) Aging What Happens If Left Untreated

doi:10.1016/S0140-6736(88)91898-3

The pivotal human trial used oral tablets