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[2] in 2016 was the main interventional study on which the ADA has relied since 2017 to recommend regular monitoring of vitamin B12 levels in individuals treated with metformin, particularly in the presence of neuropathy or anemia [9]

The neuronal pathological changes were also observed in the acquired digital images saved as uncompressed 24-bit RGB TIFF files in the software program AnalySIS (Olympus Soft Imaging System GmbH, Mnster, Germany) performing quantitative analysis of neuronal damage in the karyopyknotic areas