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It has been reported that biotic and abiotic stress often induces the overproduction of reactive oxygen species (ROS) such as the superoxide radical (O 2 ) and hydrogen peroxide (H 2 O 2 ) 14

P = 0.001) (Fig

another MoA of DMF/MMF is the direct inhibition of NF-B signalling

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Thus, while previous reports indicated that oxalate causes mitochondrial dysfunction in various cell types 22,24,55 , our current studies reveal that oxalate impairs mitochondrial respiration in hepatocytes by inhibiting PPAR-regulated FAO leading to intracellular lipid accumulation