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For most of the carcinogenic NAs, the established mechanisms of action involve metabolic activation primarily via cytochrome 450 enzymes (CYPs), and mainly through -hydroxylation, generating highly reactive, electrophilic intermediates, which can ultimately form covalent DNA adducts

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10.1111/j.2042-7158.1965.tb07562.x 131 IbusquizaP

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Hence, a high level can indicate one of several conditions including hematological malignancies, renal failure and hepatic diseases including hepatocellular carcinomas

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The nerve was cut completely through

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