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Experimental evidence presented by Kortemme and Creighton has shown that the presence of macrodipole works in alliance with hydrogen-bonding to decrease the p K a of cysteines [174]

Local argyria shows in limited regions of the body, such as patches of skin, parts of the mucous membrane, or the conjunctiva

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*Correspondence: Jian Liu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers