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It is critical to understand the difference between these two approaches

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Strains lacking ZWF1 cannot use the PPP to reduce NADP+ because this is the first reaction of the PPP and non-reversible

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The 80% increase in dentate gyrus neurogenesis and the reversal of dendritic and synaptic density loss make P21 particularly suited to the recovery phase, where the goal is not preventing further damage but restoring function