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L-carnitine: a way to decrease cellular toxicity of ifosfamide

Carnitine deficiency occurs in VPA use, and is thought to be ultimately responsible for increased ammonia production

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Dysregulation of drugblood protein binding levels would be expected to affect the bioavailability of drugs, depending on the extent of drugprotein binding

Scr: serum creatinine
J Clin Endocrinol Metab (2015) 100:21811291
