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In an effort to clarify the role of the KEAP1-NRF2 pathway in ALS, it has been revealed that the transfection of the mouse MN-like hybrid cell line (NSC-34) with the human SOD1 G93A gene causes damage in the Nrf2/ARE signalling and a reduced ability of cells to react to OS

The mechanism whether mediated by weight loss, direct cardiac effects, or reduced inflammation, remains an active area of preclinical and clinical investigation

A novel class of fungal lipoxygenases

Furthermore, MG has been shown to activate stress-related signalling pathways, such as the p38MAPK, JNK, and NF-B signalling pathways, and to increase the expression of RAGE, which can further exacerbate inflammation and oxidative stress ( Ferroptosis is an iron-dependent form of regulated cell death that has been implicated in the pathogenesis of AKI and CKD (Stockwell et al., 2017)

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MSC-Derived exosomes for Cell-Free therapy