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Abstract Introduction Alzheimers disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age

However, due to the irreversibility of the overall reaction catalyzed by the multienzyme complex, it acts as a one-way bridge : pyruvate can be decarboxylated and oxidized, and the remaining acetyl unit can be linked to CoA, but the reverse reaction, conversion of acetyl-CoA to pyruvate, is not possible

10.3389/fped.2019.00350 11 DhedaK.BoothH.HuggettJ

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