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Magnesium sulfate prevents nicotine-induced alterations in serotonin, monoamine oxidase-A activity, brain-derived neurotrophic factor, and glial fibrillary acidic protein levels To investigate the biochemical changes associated with nicotine exposure and MgSO, we analyzed serotonin, BDNF, and MAO-A activity and GFAP levels

Additionally, the modulation of cystine-glutamate exchange via the system x c has been suggested as a new strategy to diminish the excitatory glutamatergic transmission observed after drugs of abuse, while drugs that influence that systemsuch as N-acetylcysteine (NAC)were considered as promising targets for the development of novel pharmacotherapies of SUD

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I.et al (2020)

These differences also emphasise the need for additional exploration of miRNA profiles

These mediators stimulate fibroblast proliferation and extracellular matrix deposition while promoting M2 macrophage polarization, collectively accelerating pulmonary fibrogenesis ( 2.5 Oxidative stress, ferroptosis and DNA damage RCS-adsorbed Fe 2+ catalyzes hydroxyl radical (OH) generation via Fenton reactions, triggering dysregulated intracellular redox homeostasis characterized by ROS overaccumulation ( Figure 1 )