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In PD, altered Trp metabolism and disrupted AhR signaling have been observed in patients, with reductions in neuroprotective Trp metabolites frequently reported [166]

This work was funded by ShanghaiTech University, the National Program on Key Basic Research Project of China (2018YFA0507004 to W.S.), National Natural Science Foundation of China (31971362, 32171439 to W.S.) and Shanghai Natural Science Foundation Grant (18ZR1425100 to X.H.)