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doi: 10.1146/annurev-neuro-070815-013838 54 BadigerSGudipatiAUppinMKonatamMLYeramneniVKBhattacharjeeSet al

While the RDA is 2.6 mcg, studies show that higher doses of up to 1,000 mcg (1 mg) daily are generally considered safe during pregnancy, especially when treating deficiency [*]

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This occurs through multiple mechanisms

As an example, in research focusing on pancreatic ductal adenocarcinoma, Zhang et al
