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Most of the evidence pointing to a link between epigenetic mutations induced by chronic- and early-life stress-dysregulated negative feedback mechanisms comes from experimental studies

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In a large cohort study, nearly all cases of initial thyrotoxicosis evolved late hypothyroidism, with overt thyrotoxicosis occurring a median of 5 weeks after the first ICI dose and overt hypothyroidism developing a median of 14 weeks later (Muir et al

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In 2017, Williams et al