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Funding This work was supported by Tropical Medicine and Biology Platform, School of Science and School of Engineering, Monash University Malaysia

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The diversity of available animal systems, from rodents suited for genetic manipulation and mechanistic exploration to large animal models such as dogs and nonhuman primates that offer closer anatomical, microbial, and immunological similarities to humans, provides a flexible framework in which earlystage hypotheses can be refined before being tested in more clinically relevant settings
