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Because of the ubiquitous nature and broad availability of the drug, this has resulted in APAP hepatotoxicity being the most frequent cause of acute liver failure (ALF) in the US2 and other Western countries3

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Intraperitoneal (i.p.) injection of NAC to rodents increased GSH in brain and synaptosomes and offered protection against peroxynitrite, hydroxyl radicals, acrolein, and oxidative stress induced by 3-nitro-propionic acid [40