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As we age or encounter environmental stressors, our natural glutathione levels may decline, compromising our respiratory function

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

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[DOI] [PubMed] [Google Scholar] 287.Hasegawa T, Iino S, Kitakaze K, Kato T, Kabata D, Oyama N

[PubMed: 19477698] (Analysis of 20 cases of suspected kava hepatotoxicity reported to German regulatory agency, using RUCAM to assess causality, found low level of evidence largely because of lack of information on clinical course [dechallenge] and exclusion of other causes, and use of other potentially hepatotoxic medications)

Despite a promising in vitro antitumor activity, the development of this therapy faced off serious side effects, limiting its potential development as anticancer therapy
