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In addition, due to their safety, efficacy, economic and consumer compliance advantages, oral dosage forms take more majority of the drug delivery market than other routes of delivery

et al., 2021), physical inactivity (Winzer et al., 2018), and psychosocial stress ( The pathophysiology of IHD is increasingly recognized as multifaceted, involving not only large-vessel atherosclerosis but also coronary microvascular dysfunction, lipid accumulation, endothelial dysfunction, thrombosis, inflammation, and other complex mechanisms (Severino et al., 2020

47 , e130 (2019)