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This is because a positive relationship could reflect both stimulatory and inhibitory (negative feedback) processes co-occurring within the HPA axis

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Cancer patients bear a substantial burden of cardiovascular disease, with hypertension being the most common cardiovascular condition among all cancer patients (10.8%), followed by diabetes (5.3%) and dyslipidemia (1.2%) [17]

Jan 2017;96(2):e5898

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects