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Induction of Ferroptosis by Erastin

Thus, we hypothesized that the constitutive Gsta4 gene expression in the inner ears of female mice might be higher than that of male mice due to higher levels of estrogen in females

Cells were cultured in DMEM lacking glucose (Thermo Fisher Scientific, 11-966-025) with 10% dialyzed FBS (Thermo Fisher Scientific, 26400044), 100 g/mL of uridine (Sigma-Aldrich, U3750), 1 mM pyruvate (Thermo Fisher Scientific, 11360070), and either 10 mM glucose (A2494001) or 10 mM galactose (Sigma-Aldrich, G5388-100G)

Among approved drugs, participation of patients over 65 has ranged from 10 percent in 2014 to 39.9 percent in 2020, indicating a consistent increase in the share of elderly participants in trials resulting in FDA approval during this period (2021 data are yet incomplete)