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I prefer the sublingual route, as it is highly absorbable, making it a more convenient and effective option for those with pernicious anemia (this condition can create issues with absorbing B12 orally)

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Magnesium has multiple roles in cellular function and nerve transmission, and interacts with and blocks the calcium channel within NMDA receptors in a regulatory manner (85), preventing overactivation of NMDA receptors and glutamatergic excitatory action

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The documented protocol keeps the dose at the highest well-tolerated level rather than cycling off