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SIRT1, a member of sirtuins family, exerts anti-oxidant, anti-inflammatory, and anti-aging effect

This may explain why p21 overexpression alone was not sufficient to fully inhibit ferroptosis in our hands: p53 stabilization is needed together with p21 induction for complete inhibition of RNR complex expression and function

** (2020) Protein X-ray Crystallography and Drug Discovery

doi: 10.1016/j.freeradbiomed.2014.11.013

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth

Vitamins such as Vitamin C and Vitamin E play a key role in boosting immunity and protecting the body from infections, while minerals like zinc and selenium support overall metabolic health