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After the translation of IGF - IR mRNA, the 210 kDa protein product (pro-IGF-IR) is subject to endoproteolytic cleavage by the pro-protein convertases such as furin and pro-protein convertase 5, leading to the generation of chain (706 amino acids) and chain (627 amino acids) [22]

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These results suggest a possible involvement of PGRMC1 in Alzheimers disease

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