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Notch 3 signaling from the vascular endothelium drove FLS activation, and mice with genetic deletion of Notch3 were resistant to serum-induced joint inflammatory responses

[DOI] [PubMed] [Google Scholar] 1343.Wang JS, Singh H, Zhang F, Ishizuka T, Deng H, Kemp R, Wolin MS, Hintze TH, Abraham NG, Nasjletti A, Laniado-Schwartzman M

Mice without BACH1 exhibit hindered APCs growth, resulting in compromised Tcell reactions and limited defense against experimental autoimmune encephalomyelitis, a condition marked by inflammation and harm to the central nervous system

It scavenges ROS by interacting with a free thiol as a direct antioxidant [65]

Glutathione is a naturally occurring antioxidant that plays a critical role in protecting cells from oxidative stress and maintaining the immune system

AartsEEderveenTHANaaijenJZwiersMPBoekhorstJTimmermanHMet al