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For researchers submitting protocols for institutional review or documenting rationale for compound selection, the Matrixyl vs GHK-Cu evidence gap is worth noting

While the effects of these agents on DNA damage were only observed with pretreatment, all the antioxidants did show significant protective effects against radiation-induced lipid peroxidation, even when administered after irradiation [38]

Studies have shown that pretreatment with API (20 mg/kg) significantly improves the levels of hepatic antioxidant markers (GSH, CAT, GPX and SOD) in mice with MTX-induced liver injury, and reduces levels of liver function indicators (AST, ALT and ALP) and inflammatory factors (TNF- and IL-1) (Goudarzi et al., 2021)