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The HS group had significantly fewer pulmonary exacerbations, an improvement in quality of life, a reduction in absenteeism from school and work and an improvement in FEV1 of 65ml.17 A Cochrane review in 2009, including 12 trials, concluded that HS is a safe, low-cost and effective therapy in CF.18However, the HS recommendation for non-CF BE is not clear

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5.6 Prevention of DNA damage 5.7 Prevention of protein modification (RNS and chlorine) Reactive nitrogen species (RNS) and hypochlorous acid (HOCl) modify amino acids, leading to enzyme inactivation